Am J Hum Genet. 1991 Dec;49(6):1263-79.

Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.

Foroud T, Wei S, Ziv Y, Sobel E, Lange E, Chao A, Goradia T, Huo Y, Tolun A, Chessa L, Charmley P, Sanal O, Salman N, Julier C, Concannon P, McConville C, Taylor AM, Shiloh Y, Lange SK, Gatti RA.

Source

Department of Biomathematics, University of California School of Medicine, Los Angeles 90024.

Abstract

Linkage of at least two complementation groups of ataxia-telangiectasia (AT) to the chromosomal region 11q23 is now well established. We provide here an 18-point map of the surrounding genomic region, derived from linkage analysis of 40 CEPH families. On the basis of this map, 111 AT families from Turkey, Israel, England, Italy, and the United States were analyzed, localizing the AT gene(s) to an 8-cM sex-averaged interval between the markers STMY and D11S132/NCAM. A new Monte Carlo method for computing approximate location scores estimates this location as being at least 10(8) times more likely than the next most likely interval, with a support interval midway between STMY and D11S132 that is either 5.2 cM (sex-averaged and conservatively based on 3 lod scores from the maximum-location score) or 2.8 cM (male specific, based on a 2.72:1 interval-specific female-to-male distance ratio.

Comment in

Am J Hum Genet. 1992 Jun;50(6):1343-8.

PMID:: 1746555; [PubMed - indexed for MEDLINE]
PMCID:: PMC1686455

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Genetic Markers

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium. [Am J Hum Genet. 1995]
Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.
Lange E, Borresen AL, Chen X, Chessa L, Chiplunkar S, Concannon P, Dandekar S, Gerken S, Lange K, Liang T. Am J Hum Genet. 1995 Jul; 57(1):112-9.
Ataxia-telangiectasia: linkage analysis of chromosome 11q22-23 markers in Turkish families. [FASEB J. 1992]
Ataxia-telangiectasia: linkage analysis of chromosome 11q22-23 markers in Turkish families.
Sanal O, Lange E, Telatar M, Sobel E, Salazar-Novak J, Ersoy F, Morrison A, Concannon P, Tolun A, Gatti RA. FASEB J. 1992 Jul; 6(10):2848-52.
Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22. [Nucleic Acids Res. 1990]
Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.
McConville CM, Formstone CJ, Hernandez D, Thick J, Taylor AM. Nucleic Acids Res. 1990 Aug 11; 18(15):4335-43.
Review Ataxia-telangiectasia: closer to unraveling the mystery. [Eur J Hum Genet. 1995]
Review Ataxia-telangiectasia: closer to unraveling the mystery.
Shiloh Y. Eur J Hum Genet. 1995; 3(2):116-38.
Review Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23. [Int J Radiat Biol. 1994]
Review Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23.
McConville CM, Byrd PJ, Ambrose HJ, Taylor AM. Int J Radiat Biol. 1994 Dec; 66(6 Suppl):S45-56.

See reviews... See all...

Cited by 10 PubMed Central articles

Severe microcephaly with normal intellectual development: the Nijmegen breakage syndrome. [Arch Dis Child. 1995]
Severe microcephaly with normal intellectual development: the Nijmegen breakage syndrome.
Green AJ, Yates JR, Taylor AM, Biggs P, McGuire GM, McConville CM, Billing CJ, Barnes ND. Arch Dis Child. 1995 Nov; 73(5):431-4.
Ordering genes: controlling the decision-error probabilities. [Am J Hum Genet. 1993]
Ordering genes: controlling the decision-error probabilities.
Rogatko A, Zacks S. Am J Hum Genet. 1993 May; 52(5):947-57.
Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer. [Br J Cancer. 1993]
Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer.
Foulkes WD, Campbell IG, Stamp GW, Trowsdale J. Br J Cancer. 1993 Feb; 67(2):268-73.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome ...
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
Am J Hum Genet. 1991 Dec ;49(6):1263-79.

PubMed
Molecular analysis of the Smith-Magenis syndrome: a possible contiguous-gene syn...
Molecular analysis of the Smith-Magenis syndrome: a possible contiguous-gene syndrome associated with del(17)(p11.2).
Am J Hum Genet. 1991 Dec ;49(6):1207-18.

PubMed
A fragment-based approach for the discovery of isoform-specific p38alpha inhibit...
A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors.
ACS Chem Biol. 2007 May 22 ;2(5):329-36. Epub 2007 Apr 27 .

PubMed
Outcome following decompressive craniectomy in children with severe traumatic br...
Outcome following decompressive craniectomy in children with severe traumatic brain injury: a 10-year single-center experience with long-term follow up.
J Neurosurg. 2007 Apr ;106(4 Suppl):268-75.

PubMed
Differential misclassification arising from nondifferential errors in exposure m...
Differential misclassification arising from nondifferential errors in exposure measurement.
Am J Epidemiol. 1991 Nov 15 ;134(10):1233-44.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: