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    Mech Dev. 2007 Jul;124(6):441-8. Epub 2007 Mar 13.

    Two ligands signal through the Drosophila PDGF/VEGF receptor to ensure proper salivary gland positioning.

    Harris KE, Schnittke N, Beckendorf SK.

    Source

    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

    Abstract

    The Drosophila embryonic salivary gland is a migrating tissue that undergoes a stereotypic pattern of migration into the embryo. We demonstrate that the migratory path of the salivary gland requires the PDGF/VEGF pathway. The PDGF/VEGF receptor, Pvr, is strongly expressed in the salivary glands, and Pvr mutations cause abnormal ventral curving of the glands, suggesting that Pvr is involved in gland migration. Although the Pvr ligands, Pvf1 and Pvf2, have distinct expression patterns in the Drosophila embryo, mutations for either one of the ligands result in salivary gland migration defects similar to those seen in embryos that lack Pvr. Rescue experiments indicate that the PDGF/VEGF pathway functions autonomously in the salivary gland. The results of this study demonstrate that the Drosophila PDGF/VEGF pathway is essential for proper positioning of the salivary glands.

    PMID:
    17462868
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2680691
    Free PMC Article

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