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World J Gastroenterol. 2007 Mar 21;13(11):1747-51.

Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma.

Author information

  • 1Division of Gastrointestinal Oncology, Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, No. 197 Ruijin Er Road, Shanghai 200030, China. yezhengbao_ruijin@yahoo.com.cn

Abstract

AIM:

To explore the effect of intratumoral expressions of interleukin-12 (IL-12) and interleukin-18 (IL-18) on clinical features, angiogenesis and prognosis of gastric carcinoma.

METHODS:

The expressions of IL-12 and IL-18 from 50 samples of gastric cancer tissue were analyzed by immunohistochemistry, and microvessel density (MVD) was determined with microscopic imaging analysis system.

RESULTS:

The positive expression rates of IL-12 and IL-18 were 44% (22/50) and 26% (13/50), respectively. IL-12 was significantly associated with pathologic differentiation, depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, and IL-18 was closely related to distant metastasis. Intratumoral IL-12 and IL-18 expressions were not statistically related to MVD scoring. IL-12-positive patients survived significantly longer than those with IL-12-negative tumors, but there was no significant difference between IL-18-positive patients and IL-18-negative ones. The multivariate analysis with Cox proportional hazard model revealed IL-12, MVD and T stage were independent prognostic factors.

CONCLUSION:

The positive expressions of IL-12 and IL-18 can play an important role in progression and metastasis of gastric cancer, and IL-12 might be an independent factor of poor prognosis in gastric carcinoma.

PMID:
17461482
[PubMed - indexed for MEDLINE]
PMCID:
PMC4146958
Free PMC Article
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