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    Eur J Paediatr Neurol. 2007 Nov;11(6):337-40. Epub 2007 Apr 24.

    CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy.

    Buyse GM, Goemans N, Henricson E, Jara A, van den Hauwe M, Leshner R, Florence JM, Mayhew JE, Escolar DM.

    Source

    University Hospitals KU Leuven, Leuven, Herestraat 49, B-3000 Leuven, Belgium. gunnar.buyse@uz.kuleuven.ac.be

    Abstract

    The authors report a pilot open-label two-center therapeutic trial of oxatomide in 14 steroid-naive DMD boys aged 5-10 years. Comparison of linear evolutions between 3 months medication-free lead-in periods and 6 months treatment periods showed no significant differences in quantitative (QMT) and manual (MMT) measurements of muscle strength and timed functional tests. A modest mitigation of strength deterioration over time cannot be excluded.

    PMID:
    17459739
    [PubMed - indexed for MEDLINE]

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