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Am J Ophthalmol. 2007 Jun;143(6):932-939. Epub 2007 Apr 24.

Dietary macronutrient intake and five-year incident cataract: the blue mountains eye study.

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  • 1Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, Westmead, Australia.

Abstract

PURPOSE:

To investigate the relationships between dietary macronutrient intake at baseline and the five-year incidence of the three main types of cataract in older people.

DESIGN:

Population-based cohort study.

METHODS:

SETTINGS:

An urban community near Sydney, Australia.

STUDY POPULATION:

The Blue Mountains Eye Study (BMES) examined 3,654 predominantly Caucasian participants aged 49+ years during 1992 to 1994, and then 2,335 survivors (71.5%) after five years. Of these 2,335 subjects, 1988 (85%) completed a Willett-derived food frequency questionnaire (FFQ) at baseline.

OBSERVATION PROCEDURES:

A 145-item FFQ was used to assess nutrient intakes and lens photography was used to assess the presence of cataract at both time points.

MAIN OUTCOME MEASURES:

Incidence of cortical, nuclear, and posterior subcapsular (PSC) cataract was assessed via lens photographic grading following the Wisconsin cataract grading method.

RESULTS:

After adjusting for multiple known cataract risk factors, higher dietary intakes of omega-3 polyunsaturated fatty acids (n-3 PUFA) were associated with a reduced incidence of nuclear cataract. The odds ratio (OR) for subjects in the highest quintile of intake compared to those in the lowest quintile was 0.58 (95% confidence interval [CI] 0.35 to 0.97), P(trend) = .027. Similarly, for PSC cataract, higher dietary intakes of protein were protective (OR 0.28; 95% CI 0.10 to 0.76), P(trend) = .015. Dietary macronutrient intake was not associated with incident cortical cataract.

CONCLUSIONS:

Higher dietary intakes of n-3 PUFA may decrease the five-year risk of nuclear cataract, whereas higher dietary intakes of protein may decrease risk for PSC cataract.

PMID:
17459316
[PubMed - indexed for MEDLINE]
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