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Qual Life Res. 2007 Aug;16(6):947-60. Epub 2007 Apr 25.

Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report.

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  • 1Department of Preventive Medicine, Keck School of Medicine of University of Southern California, USC/Norris Comprehensive Cancer Center, 1444 Eastlake Avenue, Room 4449, Los Angeles, CA 90033, USA.

Abstract

PURPOSE:

The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors.

METHODS:

Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms.

RESULTS:

Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning.

CONCLUSION:

This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.

PMID:
17457697
[PubMed - indexed for MEDLINE]
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