Hum Genet. 2007 Jul;121(6):759-62. Epub 2007 Apr 25.

Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example.

Gardner M, Williamson S, Casals F, Bosch E, Navarro A, Calafell F, Bertranpetit J, Comas D.

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Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain.

Abstract

Extreme population differentiation, as measured by the F(ST) value, has been suggested as an indicator of recent population-specific positive selection. Elevated F(ST) values indicating high differentiation between continental groups were previously reported on a linkage disequilibrium region in the Neuregulin 1 gene, a gene which has been associated to schizophrenia. In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene.

PMID:: 17457614; [PubMed - indexed for MEDLINE]

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Extreme individual marker F(ST )values do not imply population-specific selectio...
Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example.
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