Send to:

Choose Destination
See comment in PubMed Commons below
Int Rev Immunol. 2007 Jan-Apr;26(1-2):49-72.

Regulation of type 1 diabetes by NKT cells.

Author information

  • 1INSERM U561, Université René Descartes, Hôpital Cochin/Saint Vincent de Paul. Paris. France.


Type 1 diabetes is an autoimmune disease due to the destruction of insulin-producing pancreatic beta cells. Natural Killer T (NKT) cells are a T-cell subset that links the innate and adaptive immune systems. NKT cells play a key regulatory role in type 1 diabetes. The absence of NKT cells correlates with exacerbation of type 1 diabetes, whereas an increased frequency and/or activation of NKT cells prevents beta-cell autoimmunity. Various mechanisms are involved in the protective effect of NKT cells. The goal is now to translate knowledge gained from mouse models into human therapeutics.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Informa Healthcare
    Loading ...
    Write to the Help Desk