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Int Rev Immunol. 2007 Jan-Apr;26(1-2):49-72.

Regulation of type 1 diabetes by NKT cells.

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  • 1INSERM U561, Université René Descartes, Hôpital Cochin/Saint Vincent de Paul. Paris. France.

Abstract

Type 1 diabetes is an autoimmune disease due to the destruction of insulin-producing pancreatic beta cells. Natural Killer T (NKT) cells are a T-cell subset that links the innate and adaptive immune systems. NKT cells play a key regulatory role in type 1 diabetes. The absence of NKT cells correlates with exacerbation of type 1 diabetes, whereas an increased frequency and/or activation of NKT cells prevents beta-cell autoimmunity. Various mechanisms are involved in the protective effect of NKT cells. The goal is now to translate knowledge gained from mouse models into human therapeutics.

PMID:
17454264
[PubMed - indexed for MEDLINE]
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