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Neurology. 1991 Dec;41(12):1990-2.

HTLV-I-associated myelopathy: clinicopathologic correlation with localization of provirus to spinal cord.

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  • 1Department of Medicine, University of Natal, South Africa.

Abstract

A 49-year-old South African man developed a rapidly progressive myelopathy 14 months after blood transfusion and died 1 year after the onset of symptoms. Detailed pathologic examination of the spinal cord was consistent with the diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although no HTLV-I viral particles, antigens, or nucleic acids were detected in situ, polymerase chain reaction assays revealed HTLV-I proviral DNA in cervical, thoracic, and lumbar levels of the spinal cord, with the greatest amount being detected at the thoracic level. These findings suggest that the pathogenesis of HAM/TSP depends on direct infection of neural or immune elements within the spinal cord.

PMID:
1745362
[PubMed - indexed for MEDLINE]
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