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Mol Gen Genet. 1991 Nov;230(1-2):177-85.

Association of cytochrome b translational activator proteins with the mitochondrial membrane: implications for cytochrome b expression in yeast.

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  • 1Lehrstuhl Genetik, Universität München, FRG.


The products of the nuclear genes CBS1 and CBS2 are both required for translational activation of mitochondrial apocytochrome b in yeast. We report the intramitochondrial localization of both proteins by use of specific antisera. Based on its solubilization properties the CBS1 protein is presumed to be a component of the mitochondrial membrane; the detergent concentrations needed to release CBS1 from mitochondria are almost the same as for cytochrome c1. In contrast, CBS2 behaves like a soluble protein, with some characteristics of a membrane-associated protein. A model is presented for translational activation of cytochrome b, which might also be applicable to translational regulation of other mitochondrial genes.

[PubMed - indexed for MEDLINE]
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