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RNA. 2007 Jun;13(6):860-7. Epub 2007 Apr 20.

A family of poly(U) polymerases.

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  • 1Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Abstract

The GLD-2 family of poly(A) polymerases add successive AMP monomers to the 3' end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 3' end of an RNA substrate. However, these new enzymes, which we refer to as poly(U) polymerases, add poly(U) rather than poly(A) to their RNA substrates.

PMID:
17449726
[PubMed - indexed for MEDLINE]
PMCID:
PMC1869031
Free PMC Article

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