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Cell. 2007 Apr 20;129(2):241-3.

Ephs and ephrins keep pancreatic Beta cells connected.

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  • 1Division of Cell and Molecular Physiology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston MA 02215, USA. rohit.kulkarni@joslin.harvard.edu


How insulin-secreting beta cells of the pancreas communicate with each other is largely unknown. In this issue of Cell, Konstantinova et al. (2007) show that the signaling proteins EphA and ephrin-A modulate insulin secretion, providing fresh insights into the functional significance of the clustering of beta cells, which occurs in islets.

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