J Nucl Med. 1991 Dec;32(12):2227-32.

Clinical evaluation of a scintigraphic method for diagnosing inflammations/infections using indium-111-labeled nonspecific human IgG.

Serafini AN, Garty I, Vargas-Cuba R, Friedman A, Rauh DA, Neptune M, Landress L, Sfakianakis GN.

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University of Miami/Jackson Memorial Medical Center, Florida.

Abstract

This study was undertaken as part of a Phase II study to assess the sensitivity and safety of 111In-DTPA-human IgG, an imaging agent for the detection of inflammations and/or infections. Forty patients with infection/inflammation on the basis of clinical findings, microbiologic results, and/or the basis of results from other imaging modalities were studied. For evaluation of sensitivity, whole-body images were obtained at 6-12 hr (early) and 20-28 hr (delayed) postinjection and occasionally at 48 hr. No adverse reactions were recorded in any of the 40 patients studied. Positive results were obtained in 37 of 37 evaluable subjects (100%). The test appears to be a promising method for the detection of inflammation and/or infection.

PMID:: 1744707; [PubMed - indexed for MEDLINE]

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