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Anal Bioanal Chem. 2007 Jun;388(3):637-43. Epub 2007 Apr 20.

Identification of human hepatocellular carcinoma-related proteins by proteomic approaches.

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  • 1Department of Chemistry, Texas Christian University, 2800 S. University Drive, Fort Worth, TX, 76129, USA.


Hepatocellular carcinoma (HCC) is the most common malignant liver tumor. Analysis of human serum from HCC patients using two-dimensional gel electrophoresis (2DE) combined with nano-high-performance liquid chromatography electrospray ionization tandem mass spectrometry (nano-HPLC-ESI-MS/MS) identified fourteen different proteins differentially expressed between HCC patients and the control group. Twelve proteins were up-regulated and two down-regulated. By using nano-HPLC-MS/MS system to analyze proteome in human serum, 317 proteins were identified, twenty-nine of which to high confidence levels (protein matched at last two unique peptide sequences). Of these twenty-nine proteins, six were present only in HCC patients and may serve as biomarkers for HCC.

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