Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Respir Crit Care Med. 2007 Jul 1;176(1):27-35. Epub 2007 Apr 19.

Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma.

Author information

  • 1Department of Cell Regulation, Faculty of Medicine, Kagawa University, Kagawa, Japan. kshigeki@med.kagawa-u.ac.jp

Abstract

RATIONALE:

Galectin-9 (Gal-9) belongs to the galectin family, which exhibits affinity for beta-galactosides. Gal-9 has a variety of biological activities; however, its role in allergic inflammation is unknown.

OBJECTIVES:

We evaluated the effect of a stable form of the human protein on allergic airway inflammation in a mite allergen-induced asthma model.

METHODS:

Human stable Gal-9 was given by intravenous injection to mice during antigen challenge. The effect of Gal-9 on airway inflammation and airway hyperresponsiveness (AHR) was then evaluated.

MEASUREMENTS AND MAIN RESULTS:

Gal-9 reduced AHR as well as Th2-associated airway inflammation. Furthermore, administration of Gal-9 as well as anti-CD44 monoclonal antibody inhibited the infiltration of peripheral blood Th2 cells into the airway. Interestingly, Gal-9 directly bound the CD44 adhesion molecule and inhibited interactions with hyaluronan (HA). Consistent with the concept that CD44-HA interactions mediate the migration of T cells into the lung, Gal-9 blocked CD44-dependent adhesion of BW5147 mouse T cells to HA.

CONCLUSIONS:

We conclude that Gal-9 inhibits allergic inflammation of the airway and AHR by modulating CD44-dependent leukocyte recognition of the extracellular matrix.

PMID:
17446336
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk