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Fertil Steril. 2007 Aug;88(2):494-6. Epub 2007 Apr 18.

Miniature hygrometric hot flash recorder.

Author information

  • 1Departments of Obstetrics and Gynecology and Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA. aa2613@wayne.edu <aa2613@wayne.edu>

Abstract

OBJECTIVE:

To design and test a miniature ambulatory hot flash recorder that uses neither electrodes nor gel.

DESIGN:

In the first study, putative hot flashes recorded by using a relative humidity sensor were compared with patient event marks. In the second study, relative humidity recorded by using a complete prototype recorder was compared with sternal skin conductance recordings made on a Biolog recorder, as well as with event marks.

SETTING:

University medical center.

PATIENT(S):

Ten healthy postmenopausal women reporting frequent hot flashes and using no medication.

INTERVENTION(S):

Body heating in laboratory.

MAIN OUTCOME MEASURE(S):

Positive predictive value (PPV), sensitivity, specificity.

RESULT(S):

In both laboratory studies, the PPV, sensitivity, and specificity among all three measures (relative humidity, skin conductance level, event) were 100%. In the field, a relative humidity increase of 3% per minute compared with skin conductance level-detected hot flashes yielded a PPV of 95.6%, a specificity of 95.2%, and a sensitivity of 90.9%.

CONCLUSION(S):

This device should be useful as an endpoint in clinical trials of treatments for hot flashes.

PMID:
17445808
[PubMed - indexed for MEDLINE]
PMCID:
PMC2001309
Free PMC Article

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