J Med Assoc Thai. 1991 Jun;74(6):327-30.

An in vitro study on mefloquine/quinine in Plasmodium falciparum malaria.

Jariya P, Tiewchaloren S, Mankalanond K.

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Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Abstract

An in vitro designed for determining sensitivity of Plasmodium falciparum strains isolated from Kanchanaburi Province, to Mefloquine/Quinine combination, was carried out. The MIC values of Mefloquine/Quinine for the P.falciparum strains were found to be 0.075/3.75 to 0.225/11.15 nM/ml. The changes observed following the drug treatment were an enlargement of the space between the outer and the inner limiting membrane of the parasitophorous vacuole. These changes were followed by cytoplasmic degeneration and vacuolation.

PMID:: 1744537; [PubMed - indexed for MEDLINE]

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