Display Settings:

Format

Send to:

Choose Destination
Cochrane Database Syst Rev. 2007 Apr 18;(2):CD005382.

Yizhi capsule for vascular dementia.

Author information

  • 1West China Hospital, Sichuan University, Chinese Cochrane Centre, Chinese EBM Centre, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041. txwutx@hotmail.com

Abstract

BACKGROUND:

Vascular dementia (VD) is a syndrome or diagnosis that has different causes and clinical manifestations relating to several different vascular mechanisms and changes in the brain. Some traditional Chinese herbal medicines were developed for treating VD. DH: Yizhi capsule is one such herbal concoction which is reported to improve clinical symptoms significantly. The efficacy and adverse effects of Yizhi capsule need to be reviewed systematically and assessed critically to inform clinical practice and guide the continued search for new treatment regimens.

OBJECTIVES:

To assess the effectiveness and possible adverse events of 'Yizhi capsule' in treating vascular dementia.

SEARCH STRATEGY:

The Cochrane Dementia and Cognitive Improvement Group's Specialised Register was searched on 18 September 2006 using the terms yi-zhi, "yi zhi" and yizhi. This database contains trial references from major health care databases and ongoing trial database and is up to date. In addition the review authors searched a variety of Chinese databases.

SELECTION CRITERIA:

Randomised, placebo controlled trials in which patients with vascular dementia were treated with 'Yizhi capsule' were included.

DATA COLLECTION AND ANALYSIS:

Two authors independently assessed trial quality and extracted data. We telephoned study authors for missing information as to whether treatment allocation was randomised and other methodological details.

MAIN RESULTS:

No studies were found that met the inclusion criteria. We identified nine references to trials which included the term 'Yizhi capsule' in the description of the interventions. Two study authors were contacted by telephone and we discovered that the allocation methods they had used were not actually randomised. Four references were describing the same study. Three studies were excluded because 'positive drugs' were used as a control.

AUTHORS' CONCLUSIONS:

There is no evidence from randomised controlled trials to support or proscribe against the use of 'Yizhi capsule' as a treatment for vascular dementia.

PMID:
17443586
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk