Trends Genet. 2007 Jul;23(7):321-5. Epub 2007 Apr 18.

Coevolution of genomic intron number and splice sites.

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Allan Wilson Centre for Molecular Evolution and Ecology, Massey University, Palmerston North, New Zealand.

Abstract

Spliceosomal intron numbers and boundary sequences vary dramatically in eukaryotes. We found a striking correspondence between low intron number and strong sequence conservation of 5' splice sites (5'ss) across eukaryotic genomes. The phylogenetic pattern suggests that ancestral 5'ss were relatively weakly conserved, but that some lineages independently underwent both major intron loss and 5'ss strengthening. It seems that eukaryotic ancestors had relatively large intron numbers and 'weak' 5'ss, a pattern associated with frequent alternative splicing in modern organisms.

PMID:: 17442445; [PubMed - indexed for MEDLINE]

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RNA Splice Sites

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