OBJECTIVE: To investigate the diagnosis and treatment of rhinogenous ophthalmocele, to reduce misdiagnosis and missed diagnosis rate. METHOD: Sixty-two patients with rhinogenous ophthalmocele disease in our hospital from January 1998 to October 2005 were retrospectively analyzed. RESULT: Sixty-two patients with rhinogenous ophthalmocele disease, 18 frontal-ethmoid sinus cystis, 12 nasosinusitis, 6 fungal frontal sinusitis, 10 maxillary sinus carcinoma, 4 olfactory nerve tumour, 6 traumatic carotid cavernous fistula, 6 ethmoidal sinus osteoma. The rhinogenous ophthalmocele caused by frontal-ethmoid sinus cystis and nasosinusitis and ethmoidal sinus osteoma were cured. The maxillary sinus carcinomas were followed up for 5 years, 2 examples are alive, 2 examples are lost. The olfactory nerve tumours were death in 2 years after operation. The 2 traumatic carotid cavernous fistula were death, 4 were cured. CONCLUSION: The disease with rhinogenous ophthalmocele was easily misdiagnosed for the low incidence of the disease. According to eyes reasons of ophthalmocele, choose the suitable operational method, it is satisfied with the result of treatment.