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Infect Immun. 2007 Jul;75(7):3425-33. Epub 2007 Apr 16.

Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand.

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  • 1Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20906, USA.

Erratum in

  • Infect Immun. 2007 Sep;75(9):4671.

Abstract

Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.

PMID:
17438034
[PubMed - indexed for MEDLINE]
PMCID:
PMC1932940
Free PMC Article
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