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J Travel Med. 2007 May-Jun;14(3):173-6.

Immunogenicity study of abbreviated rabies preexposure vaccination schedules.

Author information

  • 1Queen Saovabha Memorial Institute of the Thai Red Cross Society and the Department of Medicine, King Chulalongkorn University Hospital, Bangkok, Thailand.

Abstract

OBJECTIVE:

To evaluate abbreviated preexposure rabies vaccination schedules that would reduce cost and shorten time required for completion.

METHOD:

A random prospective immunogenicity study, using a group of 96 volunteer preclinical veterinary students, primary school children, and hospital-based health care workers. They were divided into six groups and administered abbreviated schedules of preexposure tissue culture rabies vaccines. Neutralizing antibodies were determined on days 0 and 360, and following boosters on days 367 and 374.

RESULTS:

All subjects, including one group that received only 0.1 mL intradermally at two sites on one day, had detectable neutralizing antibody titers 1 year later and responded with an accelerated antibody response when given booster injections.

CONCLUSION:

It might be possible to develop a 1-week and even one clinic visit preexposure vaccine schedule that would provide at least 1 year of immune memory.

PMID:
17437473
[PubMed - indexed for MEDLINE]
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