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Curr Opin Drug Discov Devel. 2007 Mar;10(2):122-9.

RNA interference for studying the molecular basis of neuropsychiatric disorders.

Author information

  • 1Novartis Institutes for BioMedical Research (NIBR), Neuroscience Research, WSJ 386-745, CH-4002 Basel, Switzerland. Daniel.hoyer@novartis.com

Abstract

RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by sequence-specific mRNA degradation, which is triggered by short double-stranded RNA. This mechanism can be efficiently induced both in vitro and in vivo by expressing target-complementary short hairpin RNA (shRNA) from non-viral and viral vectors, or by the application of short interfering RNA (siRNA). The design of highly selective and efficacious siRNA and shRNA has become commonplace, owing to continuous progress in modeling, bioinformatics and chemistry. Thus, RNAi is attractive for use in functional genomics, target and pathway validation and, potentially, human therapeutics. This review highlights recent findings in the field of RNAi with emphasis on neuropsychiatric aspects.

PMID:
17436547
[PubMed - indexed for MEDLINE]
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