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J Invest Dermatol. 2007 May;127(5):994-5.

Patterning skin pigmentation via dickkopf.

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  • 1Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA.


One of the striking regional variations in skin is its pigmentation. Yamaguchi et al. further dissect the mechanism of regional pigmentation by assessing the effects of dickkopf 1 (DKK1), an antagonist of the Wnt pathway produced in lightly pigmented skin, on melanocyte gene expression. The results provide a plethora of candidate genes that may mediate DKK1's inhibitory effects on melanocyte function.

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