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Nat Methods. 2007 May;4(5):401-3. Epub 2007 Apr 15.

A model system for analyzing somatic mutations in Drosophila melanogaster.

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  • 1University of Texas at San Antonio, San Antonio, Texas 78249, USA.

Abstract

Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.

PMID:
17435764
[PubMed - indexed for MEDLINE]
PMCID:
PMC2723853
Free PMC Article

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