Immunoassay-based diagnostic point-of-care technol...[Ann N Y Acad Sci. 2007]

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1: Ann N Y Acad Sci. 2007 Mar;1098:486-9. Links

Immunoassay-based diagnostic point-of-care technology for oral specimen.

Munjal S, Miethe P, Netuschil L, Struck F, Maier K, Bauermeister C.

Dentognostics GmbH, Jena, Germany.

We have outlined our progress in developing a novel point-of-care platform to quantify micro-organisms causing dental infections and/or inflammatory markers reflecting an oral disease status. This system is based on a sandwich immunoassay technology known as ABICAP (Antibody Immuno Column for Analytical Processes) using poly-horseradish peroxidase conjugates. This assay enabled us to quantify 500 colony-forming units of Streptococcus sobrinus per milliliter of saliva. The platform allows rapid and convenient performance chairside of such tests by a dentist or dental hygienist within 20 minutes at the dental office.

PMID: 17435155 [PubMed - indexed for MEDLINE]

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