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Lancet. 2007 Apr 14;369(9569):1287-301.

Autosomal dominant polycystic kidney disease.

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  • 1Mayo Clinic College of Medicine, Rochester, MN 55905, USA. torres.vicente@mayo.edu

Abstract

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of the disorder's underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective treatments.

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PMID:
17434405
[PubMed - indexed for MEDLINE]
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