Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2007 Jun;23(6):301-9. Epub 2007 Apr 16.

Playing hide and seek with mammalian meiotic crossover hotspots.

Author information

  • 1Institute of Human Genetics, UPR1142-CNRS, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France.

Abstract

Crossovers (COs) are essential for meiosis and contribute to genome diversity by promoting the reassociation of alleles, and thus improve the efficiency of selection. COs are not randomly distributed but are found at specific regions, or CO hotspots. Recent results have revealed the historical recombination rates and the distribution of hotspots across the human genome. Surprisingly, CO hotspots are highly dynamic, as shown by differences in activity between individuals, populations and closely related species. We propose a role for DNA methylation in preventing the formation of COs, a regulation that might explain, in part, the correlation between recombination rates and GC content in mammals.

PMID:
17434233
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk