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Curr Opin Immunol. 2007 Jun;19(3):309-14. Epub 2007 Apr 12.

PD-1 and its ligands in T-cell immunity.

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  • 1Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

The past year has seen significant advances in our understanding of the critical roles of negative immunoregulatory signals delivered by the programmed death 1 (PD-1)-PD-1 ligand (PD-L) pathway in regulating T-cell activation and tolerance. Emerging evidence indicates that PD-Ls play an essential role on dendritic cells (DCs), both directly during DC-T cell interactions and indirectly through signaling into the DC. Recent studies point to a novel role for PD-L1 in maintaining tissue tolerance. Finally, PD-1 has recently been shown to be highly expressed on exhausted T cells during chronic viral infection, and blockade of PD-1 or PD-L1 can revive exhausted T cells, enabling them to proliferate and produce effector cytokines.

PMID:
17433872
[PubMed - indexed for MEDLINE]
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