Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Med Hypotheses. 2007;69(5):1090-2. Epub 2007 Apr 11.

Gut osmolarity: a key environmental cue initiating the gastrointestinal phase of Listeria monocytogenes infection?

Author information

  • 1Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland. r.sleator@ucc.ie


In addition to the severe invasive systemic disease of listeriosis, recent evidence suggests that the Gram-positive intracellular bacterial pathogen Listeria monocytogenes is also a causative agent of febrile gastroenteritis. We examined the listerial response to stresses normally encountered in the upper small intestine and demonstrate that osmotic stress appears to be at the top of the hierarchy of stress responses during gastrointestinal residence. Furthermore, we suggest that the increased osmolarity of the gastrointestinal lumen may be interpreted as an environmental cue signalling gut entry and that the underlying genetic element governing this response is the alternative stress sigma factor sigma(B).

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk