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Virology. 2007 Aug 1;364(2):454-65. Epub 2007 Apr 11.

Functional characterization of chimpanzee cytomegalovirus chemokine, vCXCL-1(CCMV).

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  • 1Department of Microbiology, University of Tennessee, Walters Life Sciences Rm F417, Knoxville, TN 37996, USA.

Abstract

Human cytomegaloviruses (HCMVs) are important pathogens in immunocompromised patients and newborns. The viral chemokine, vCXCL-1, of the Toledo (Tol) strain of HCMV has been implicated in HCMV virulence. Chimpanzee CMV (CCMV) has several genes with similarity to the vCXCL-1(Tol) gene, UL146. In order to test whether the CCMV viral chemokine, vCXCL-1(CCMV), is similar to vCXCL-1(Tol), we characterized its function in vitro. Receptor binding, activation, chemotaxis, signaling, and apoptosis in neutrophils were compared between vCXCL-1(Tol) and vCXCL-1(CCMV) and host chemokines. Although the homologues had similar activation potentials, chemotactic properties, and signaling, vCXCL-1(CCMV) had a approximately 70-fold lower affinity for CXCR2 and displayed differences in integrin upregulation and neutrophil apoptosis. These data demonstrate that in spite of extensive amino acid variability in vCXCL-1, CCMV may provide a model for assessing the role of vCXCL-1 in CMV pathogenesis in vivo.

PMID:
17433398
[PubMed - indexed for MEDLINE]
PMCID:
PMC2665277
Free PMC Article
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