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    Cytogenet Cell Genet. 1991;57(4):179-83.

    A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini.

    Source

    Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

    Abstract

    Two cosmid clones, cG1A3 and cG1A6, containing large blocks of a telomeric repeat sequence, (TTAGGG)n, were isolated independently. Restriction mapping and fingerprinting studies suggested that cosmid cG1A6 is entirely contained within cG1A3. Competitive in situ hybridization localized cG1A3 to 14 different human telomeres and one internal site at 2q14----q21, indicating the presence of a subtelomeric low-copy repeat within this cosmid.

    PMID:
    1743071
    [PubMed - indexed for MEDLINE]

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