Curr Oncol Rep. 2007 May;9(3):226-33.

Immunotherapy for prostate cancer.

Source

University of California, San Francisco, San Francisco, CA 94143-0511, USA. Lawrence.fong@ucsf.edu

Abstract

Whereas androgen deprivation and chemotherapy have become the cornerstone of therapy for advanced prostate cancer, novel therapies are being developed that may expand upon currently available treatments. The identification of antigens expressed by prostate tissue and/or prostate cancer that are recognized by T cells or antibodies creates opportunities to develop novel immunotherapeutic approaches including tumor vaccines. Proteins expressed in prostate cancer-including prostate-specific antigen, prostatic acid phosphatase, and prostate membrane antigen-have been used as immunologic targets for immunotherapy. Moreover, innovations in cancer genomics and proteomics also will aid in the identification of immunologic targets. Emerging trials have demonstrated that immunotherapy may generate not only immune responses in patients but also clinical responses. Future studies will be directed at capitalizing on these findings.

PMID:: 17430695; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Antigens, Neoplasm

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Medical

Prostate Cancer - MedlinePlus Health Information

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Related citations in PubMed

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Cited by 3 PubMed Central articles

Review Prostate cancer as a model for tumour immunotherapy. [Nat Rev Immunol. 2010]
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Wada S, Yoshimura K, Hipkiss EL, Harris TJ, Yen HR, Goldberg MV, Grosso JF, Getnet D, Demarzo AM, Netto GJ, et al. Cancer Res. 2009 May 15; 69(10):4309-18. Epub 2009 May 12.
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Fassò M, Waitz R, Hou Y, Rim T, Greenberg NM, Shastri N, Fong L, Allison JP. Proc Natl Acad Sci U S A. 2008 Mar 4; 105(9):3509-14. Epub 2008 Feb 26.

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