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1: Parasite Immunol. 2007 May;29(5):267-9.Click here to read Links

Significant differences in GM allotype frequencies between two sympatric tribes with markedly differential susceptibility to malaria.

Pandey JP, Nasr A, Rocca KM, Troy-Blomberg M, Elghazali G.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA. pandeyj@musc.edu

Fulani and Masaleit, sympatric tribes in eastern Sudan, are characterized by marked differences in susceptibility to Plasmodium falciparum malaria. To determine whether the two tribes differ in the frequency of immunoglobulin GM/KM allotypes, which are associated with immunity to several pathogens, serum samples from 50 Fulani and 50 age- and sex-matched Masaleit subjects were allotyped for several GM/KM determinants. The distribution of GM phenotypes as a whole, as well as a particular combination of KM and GM phenotypes, differed significantly between the two tribes (P = 0.03). These data suggest that GM allotypes may contribute to the genetic aetiology of malaria.

PMID: 17430550 [PubMed - indexed for MEDLINE]