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Genome Biol. 2007;8(4):R55.

A major zebrafish polymorphism resource for genetic mapping.

Author information

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-0275, USA. Kevin.bradley@vanderbilt.edu

Abstract

We have identified 645,088 candidate polymorphisms in zebrafish and observe a single nucleotide polymorphism (SNP) validation rate of 71% to 86%, improving with polymorphism confidence score. Variant sites are non-random, with an excess of specific novel T- and A-rich motifs. We positioned half of the polymorphisms on zebrafish genetic and physical maps as a resource for positional cloning. We further demonstrate bulked segregant analysis using the anchored SNPs as a method for high-throughput genetic mapping in zebrafish.

PMID:
17428331
[PubMed - indexed for MEDLINE]
PMCID:
PMC1896001
Free PMC Article

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