Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Mol Med (Berl). 2007 Oct;85(10):1047-56. Epub 2007 Apr 11.

Stromal-cell regulation of natural killer cell differentiation.

Author information

  • 1Laboratoire Immunit√© Cellulaire Antivirale, D√©partement d'Immunologie, Institut Pasteur, 75724, Paris Cedex 15, France. clroth@pasteur.fr

Abstract

Natural killer (NK) cells are bone-marrow-derived lymphocytes that play a crucial role in host defense against some viral and bacterial infections, as well as against tumors. Their phenotypic and functional maturation requires intimate interactions between the bone marrow stroma and committed precursors. In parallel to the identification of several phenotypic and functional stages of NK cell development, recent studies have shed new light on the role of stromal cells in driving functional maturation of NK cells. In this review, we provide an overview of the role of bone marrow microenvironment in NK cell differentiation.

PMID:
17426948
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk