Nat Rev Mol Cell Biol. 2007 May;8(5):379-93. Epub 2007 Apr 11.

The spindle-assembly checkpoint in space and time.

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Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. andrea.musacchio@ifom-leo-campus.it

Abstract

In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores--structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.

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The spindle-assembly checkpoint in space and time.

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