Display Settings:

Format

Send to:

Choose Destination
Br J Cancer. 2007 May 7;96(9):1439-41. Epub 2007 Apr 10.

Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study.

Author information

  • 1Centre for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. r.c.reulen@bham.ac.uk

Abstract

We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring. Exposure to high-dose gonadal irradiation was not associated with a significant alteration in offspring sex ratio compared to low doses (men: P=0.58, women: P=0.66). There was also no evidence that the ratio varied with time since cancer diagnosis when comparing survivors treated with radiotherapy vs those without (men: P=0.51; women: P=0.46). This, the largest study to date, finds no evidence that exposure to radiation affects the offspring sex ratio among survivors of childhood cancer.

PMID:
17426701
[PubMed - indexed for MEDLINE]
PMCID:
PMC2360164
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk