Adv Food Nutr Res. 2007;52:141-236.

Tetrodotoxin poisoning.

Source

Department of Food Science, National Taiwan Ocean University Taiwan, Taiwan, Republic of China.

Abstract

Tetrodotoxin (TTX) is one of the most potent and oldest known neurotoxins. The poisoning cases due to ingestion of TTX-containing marine animals, especially for puffer, have frequently occurred in Asia since a long time ago. This chapter describes various topics on TTX poisoning including the tendency of poisoning incidents, typical case report, treatment and prevention, biology distribution, original source, infestation mechanism, detection methods, characteristics of chemistry and pharmacology, and therapeutic application. Furthermore, the protocols for how to make puffer safe to eat and how to prevent puffer products made from toxic puffers have been suggested. Finally, the biological significance and neurophysiological role of TTX have been elucidated and TTX may act as an important drug like anesthetic in future.

PMID:: 17425946; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Medical

Molecular Biology Databases

TETRODOTOXIN - HSDB

Supplemental Content

Related citations

Determination of tetrodotoxin and its analogs in the puffer fish Takifugu oblongus from Bangladesh by hydrophilic interaction chromatography and mass-spectrometric detection. [Anal Bioanal Chem. 2007]
Determination of tetrodotoxin and its analogs in the puffer fish Takifugu oblongus from Bangladesh by hydrophilic interaction chromatography and mass-spectrometric detection.
Diener M, Christian B, Ahmed MS, Luckas B. Anal Bioanal Chem. 2007 Nov; 389(6):1997-2002. Epub 2007 Sep 27.
Distribution of tetrodotoxin, saxitoxin, and their analogs among tissues of the puffer fish Fugu pardalis. [Toxicon. 2006]
Distribution of tetrodotoxin, saxitoxin, and their analogs among tissues of the puffer fish Fugu pardalis.
Jang J, Yotsu-Yamashita M. Toxicon. 2006 Dec 15; 48(8):980-7. Epub 2006 Aug 14.
Rapid screening of tetrodotoxin in urine and plasma of patients with puffer fish poisoning by HPLC with creatinine correction. [Food Addit Contam Part A Chem Anal Control ...]
Rapid screening of tetrodotoxin in urine and plasma of patients with puffer fish poisoning by HPLC with creatinine correction.
Yu CH, Yu CF, Tam S, Yu PH. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Jan; 27(1):89-96.
Review An overview of the marine food poisoning in Mexico. [Toxicon. 1998]
Review An overview of the marine food poisoning in Mexico.
Sierra-Beltrán AP, Cruz A, Núñez E, Del Villar LM, Cerecero J, Ochoa JL. Toxicon. 1998 Nov; 36(11):1493-502.
Review Tetrodotoxin--distribution and accumulation in aquatic organisms, and cases of human intoxication. [Mar Drugs. 2008]
Review Tetrodotoxin--distribution and accumulation in aquatic organisms, and cases of human intoxication.
Noguchi T, Arakawa O. Mar Drugs. 2008 May 28; 6(2):220-42. Epub 2008 May 28.

See reviews... See all...

Cited by 2 PubMed Central articles

Toxic marine puffer fish in Thailand seas and tetrodotoxin they contained. [Toxins (Basel). 2011]
Toxic marine puffer fish in Thailand seas and tetrodotoxin they contained.
Chulanetra M, Sookrung N, Srimanote P, Indrawattana N, Thanongsaksrikul J, Sakolvaree Y, Chongsa-Nguan M, Kurazono H, Chaicumpa W. Toxins (Basel). 2011 Oct; 3(10):1249-62. Epub 2011 Oct 18.
Natural products from ethnodirected studies: revisiting the ethnobiology of the zombie poison. [Evid Based Complement Alternat Med. 2012]
Natural products from ethnodirected studies: revisiting the ethnobiology of the zombie poison.
Albuquerque UP, Melo JG, Medeiros MF, Menezes IR, Moura GJ, Asfora El-Deir AC, Alves RR, de Medeiros PM, de Sousa Araújo TA, Alves Ramos M, et al. Evid Based Complement Alternat Med. 2012; 2012:202508. Epub 2011 Oct 2.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tetrodotoxin poisoning.
Tetrodotoxin poisoning.
Adv Food Nutr Res. 2007 ;52:141-236.

PubMed
Clinical efficacy of three common treatments in acute otitis externa in primary ...
Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial.
BMJ. 2003 Nov 22 ;327(7425):1201-5.

PubMed
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplas...
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.
J Cell Biol. 2003 Mar 31 ;160(7):1115-27.

PubMed
The metabolic syndrome and cardiovascular disease: part 2.
The metabolic syndrome and cardiovascular disease: part 2.
Prev Cardiol. 2008 Fall ;11(4):223-9.

PubMed
Control of cystic fibrosis transmembrane conductance regulator expression by BAP...
Control of cystic fibrosis transmembrane conductance regulator expression by BAP31.
J Biol Chem. 2001 Jun 8 ;276(23):20340-5. Epub 2001 Mar 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: