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J Antibiot (Tokyo). 2007 Feb;60(2):153-7.

Carbonarones A and B, new bioactive gamma-Pyrone and alpha-Pyridone derivatives from the marine-derived fungus Aspergillus carbonarius.

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  • 1Key Laboratory of Marine Drugs, Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, PR China.


Two new secondary metabolites, carbonarones A (1) and B (2), were obtained from the culture of the marine-derived fungus Aspergillus carbonarius isolated from the marine sediment collected at Weizhou island of China. Based on ESIMS, 1D and 2D NMR data, and the X-ray crystallographic analysis, their structures were elucidated as 6-benzyl-4-oxo-4H-pyran-3-carboxamide and 6-benzyl-4-hydroxy-2-oxo-1, 2-dihydropyridine-3-carbaldehyde, respectively. 1 and 2 showed moderate cytotoxicity against K562 cells with IC(50) values of 56.0 and 27.8 mug/ml, respectively.

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