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Arch Neurol. 2007 Apr;64(4):530-4.

Continuum of frontal lobe impairment in amyotrophic lateral sclerosis.

Author information

  • 1Department of Neurology, ALS Center, University of California, San Francisco, CA 94117, USA. jennifer.murphy@ucsf.edu

Abstract

OBJECTIVE:

To identify the nature and prevalence of cognitive and behavioral abnormalities in patients with amyotrophic lateral sclerosis (ALS).

DESIGN:

Survey of clinical characteristics.

SETTING:

Multidisciplinary clinic within a university medical center. Patients A volunteer sample of 30 new patients with ALS were recruited consecutively. Of those invited, 23 participants (20 with sporadic ALS and 3 with familial ALS) enrolled. Participants ranged in age from 27 to 80 years (mean age, 56.5 years); the education level ranged from 12 to 21 years (mean education level, 3.5 years of college); and 17 participants (74%) were male.

MAIN OUTCOME MEASURES:

Neuropsychological tests, neurobehavioral interviews, and structured magnetic resonance imaging.

RESULTS:

Patients were classified into subtypes of frontotemporal lobar degeneration (n = 5), suspected Alzheimer disease (n = 1), and subthreshold variants of cognitive impairment (n = 2), behavioral impairment (n = 4), and cognitively and behaviorally normal (n = 11). Five neuropsychological tests, 2 behavioral abnormalities, and right hemisphere gray matter reductions differentiated patients into normal and abnormal groups.

CONCLUSIONS:

In this sample, a sizable proportion of patients with ALS possess a range of behavioral and cognitive changes that lie on a spectrum of frontotemporal impairment. Right hemisphere atrophy may be a biomarker for cognitive impairment in patients with ALS.

PMID:
17420314
[PubMed - indexed for MEDLINE]
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