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Cell. 2007 Apr 6;129(1):19-20.

How a home-grown T cell receptor interacts with a foreign landscape.

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  • 1The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia. <>


The ability of a T cell receptor (TCR) to directly recognize foreign (allogeneic)-major histocompatibility complex (MHC) molecules underlies T cell-mediated rejection in patients receiving allogeneic organ transplants. In this issue, Colf et al. (2007) reveal that instead of mimicking the interactions formed with a self MHC, a single TCR adopts a completely different strategy to recognize a foreign MHC.

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