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    Neurosci Res. 2007 Jul;58(3):219-25. Epub 2007 Mar 13.

    Watching neuronal circuit dynamics through functional multineuron calcium imaging (fMCI).

    Source

    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

    Abstract

    Functional multineuron calcium imaging (fMCI) is a large-scale optical recording technique that monitors the spatiotemporal pattern of action potentials, all at once, from large neuron populations. fMCI has unique advantages, including: (i) simultaneous recording from >1000 neurons in a wide area, (ii) single-cell resolution, (iii) identifiable location of neurons and (iv) detection of non-active neurons during the observation period. We review herein the principle, history, utility and limitations of fMCI.

    PMID:
    17418439
    [PubMed - indexed for MEDLINE]

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