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J Biochem. 2007 May;141(5):615-9. Epub 2007 Apr 6.

Crucial roles for chromatin dynamics in cellular memory.

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  • 1Department of Developmental Genetics, National Institute of Genetics, Sokendai, Japan.


Cellular memory is defined as a long-term maintenance of a particular pattern of gene expression through many rounds of cell division or even after cell division. It is critical for development and differentiation of multicellular organisms. Chromatin dynamics including histone modification, histone replacement and chromatin remodeling play key roles in cellular memory.

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