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Spine (Phila Pa 1976). 2007 Apr 1;32(7):816-23.

Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pain.

Author information

  • 1Center for Cost and Outcomes Research, and Department of Orthopedics and Sports Medicine, University of Washington, Seattle, WA 98104-2499, USA. mirza@u.washington.edu

Abstract

STUDY DESIGN:

Systematic review of randomized trials comparing surgical to nonsurgical treatment of discogenic back pain.

OBJECTIVE:

Compare research methods and results.

SUMMARY OF BACKGROUND DATA:

Recent reports have increased debate about the role of surgery in the treatment of chronic back pain associated with lumbar disc degeneration. We conducted a systematic review of randomized trials comparing lumbar fusion surgery to nonsurgical treatment of chronic back pain associated with lumbar disc degeneration.

METHODS:

A literature search identified 5 randomized trials that compared fusion to nonoperative treatment for chronic low back pain. Excluding 1 trial for spondylolisthesis, we compared study participants, interventions, analyses, and outcomes in 4 trials that focused on nonspecific chronic back.

RESULTS:

All trials enrolled similar subjects. One study suggested greater improvement in back-specific disability for fusion compared to unstructured nonoperative care at 2 years, but the trial did not report data according to intent-to-treat principles. Three trials suggested no substantial difference in disability scores at 1-year and 2-years when fusion was compared to a 3-week cognitive-behavior treatment addressing fears about back injury. However, 2 of these trials were underpowered to identify clinically important differences. The third trial had high rates of cross-over (>20% for each treatment) and loss to follow-up (20%); it is unclear how these affected results.

CONCLUSIONS:

Surgery may be more efficacious than unstructured nonsurgical care for chronic back pain but may not be more efficacious than structured cognitive-behavior therapy. Methodological limitations of the randomized trials prevent firm conclusions.

Comment in

PMID:
17414918
[PubMed - indexed for MEDLINE]
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