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Pediatr Res. 2007 May;61(5 Pt 2):17R-23R.

Epigenetics and microRNAs.

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  • 1Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.


MicroRNAs (miRNAs) regulate protein-coding genes post transcriptionally in higher eukaryotes. Argonaute proteins are important in miRNA regulation and are also implicated in epigenetic mechanisms such as histone modifications and DNA methylation. Here, we review miRNA regulation and outline its connections to epigenetics.

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