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Med Hypotheses. 2007;69(4):731-40. Epub 2007 Apr 6.

Autism, asthma, inflammation, and the hygiene hypothesis.

Author information

  • Gene Expression and Genomics Unit, RRB, TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. beckerk@grc.nia.nih.gov

Abstract

Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging, tumor development and tumor rejection, cardiovascular pathologies, metabolic disorders, as well as neurological and psychiatric disorders. This paper compares parallel aspects of autism and inflammatory disorders with an emphasis on asthma. These comparisons include epidemiological, morphometric, molecular, and genetic aspects of both disease types, contributing to a hypothesis of autism in the context of the immune based hygiene hypothesis. This hypothesis is meant to address the apparent rise in the prevalence of autism in the population.

PMID:
17412520
[PubMed - indexed for MEDLINE]
PMCID:
PMC2048743
Free PMC Article

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