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1: Biol Pharm Bull. 2007 Apr;30(4):791-4. Links

Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines.

Suzuki S, Masui Y, Ohnuki M, Miyakoda G, Mori T, Nakajima K, Sato M.

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. suzukis@ph.bunri-u.ac.jp

In this study, we examined the effect of Cilostazol to induce metallothionein (MT) in vivo and in vitro. Intraperitoneal injection of Cilostazol increased the expression of both MT-1 and MT-2 mRNA and total MT protein in the mouse liver. Cilostazol also augmented MT-1 mRNA levels in the murine brain. In vitro exposure to Cilostazol significantly augmented intracellular MT protein levels in cultured human brain microvascular endothelial cells (HBMEC) and in the neuroblastoma cell line IMR32. Taken together, these findings suggest that Cilostazol is an inducer of MT in the murine liver and brain, and that it has the potential to directly induce MT in cells. The contribution of the anti-oxidative effect of MT to the anti-stroke effect of Cilostazol was discussed.

PMID: 17409522 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Cilostazol (Pletal® )

    Cilostazol is used to reduce the symptoms of intermittent claudication (pain in the legs that happens when walking and goes away with rest). Cilostazol helps people walk a longer distance before leg pain starts.

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