Medicina (B Aires). 2007;67(1):63-70.

[The role of dendritic cells in the infection by HIV and HCV].

[Article in Spanish]

Belmonte L, Parodi C, Bare P, Baston M, Bracco MM, Ruibal-Ares B.

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Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.

Abstract

Dendritic cells are most important as antigen presenting cells during the induction of an effective immune response. Therefore, it is important to study their role during the generation of persistent or chronic viral infections, such as HIV or HCV infection. In this review we shall describe the phenotypic and functional characteristics of the different classes of dendritic cells and of their membrane receptors. Their participation in defence or facilitation mechanisms involved in the immune response against these viruses will be discussed. It is important to take this knowledge into account when trying to design therapeutic strategies for protection or reconstruction of the immune system that may be altered as a consequence of infection with HIV or HCV.

PMID:: 17408026; [PubMed - indexed for MEDLINE]

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