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    Planta Med. 1983 Nov;49(11):185-7.

    Antihepatotoxic Principles of Curcuma longa Rhizomes1.

    Source

    Pharmaceutical Institute, Tohoku University, Sendai, Japan.

    Abstract

    An extract of the crude drug "ukon", the rhizomes of CURCUMA LONGA, exhibited intense preventive activity against carbon tetrachloride-induced liver injury IN VIVO and IN VITRO. The extract was subjected to fractionation by monitoring the activity by the IN VITRO assay methods employing carbon tetrachloride- and galactosamine-produced cytotoxicity in primary cultured rat hepatocytes. Curcuminoids were shown to possess significant antihepatotoxic action. The liver protective effects of some analogues of ferulic acid and p-coumaric acid, probable metabolites of the curcuminoids, were also evaluated.

    PMID:
    17405047
    [PubMed - in process]

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